catalog number :
MBS140157
products full name :
Mouse Anti Human Granulocyte Colony Stimulating Factor Biotinylated
products short name :
Granulocyte Colony Stimulating Factor Biotinylated
products name syn :
G CSF Antibody, Biotin; Granulocyte Colony Stimulating Factor, Mouse Anti-Human, Biotin; CSF-3; MGI-1G; GM-CSF beta; Pluripoietin; Filgrastim; Lenograstim; G-CSF; MGC45931; GCSF; GCSF Biotin
other names :
granulocyte colony-stimulating factor isoform b; Granulocyte colony-stimulating factor; granulocyte colony-stimulating factor; filgrastim; granulocyte-colony stimulating factor; lenograstim; pluripoietin; colony stimulating factor 3 (granulocyte); Pluripoietin; INN: Filgrastim; INN: Lenograstim
products gene name :
GCSF
other gene names :
CSF3; CSF3; GCSF; CSF3OS; C17orf33; C17orf33; GCSF; G-CSF
uniprot entry name :
CSF3_HUMAN
concentration :
1 mg/ml in PBS (after reconstitution).
storage stability :
In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.
tested application :
ELISA (EIA), Western Blot (WB), Intra-cellular staining
app notes :
Direct ELISA, Western Blot, Intra-cellular staining. For intra-cellular staining use 10 ul per 1,000,000 cells.
other info2 :
Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: r.Human G-CSF.
products categories :
ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
products description :
Introduction: GCSF is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for this gene.Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This csf induces granulocytes.
ncbi acc num :
NP_757373.1
ncbi gb acc num :
NM_172219.2
ncbi mol weight :
18,434 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Malaria Pathway (152665); Malaria Pathway (152657); PI3K-Akt Signaling Pathway (692234)
ncbi summary :
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
uniprot summary :
G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Cell cycle regulation; Cytokine; Secreted. Chromosomal Location of Human Ortholog: 17q11.2-q12. Cellular Component: extracellular space. Molecular Function: enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding. Biological Process: granulocyte differentiation; positive regulation of myeloid cell differentiation; positive regulation of protein binding; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; immune response