catalog number :
MBS140151
products full name :
Rat Anti Mouse CD8
products short name :
CD8
products name syn :
CD8 Antibody; CD8, Rat Anti-Mouse; CD8; MAL; p32
purity :
Ion Exchange Column.
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
other info2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified Mouse LN T cells. Antibody Properties: Cytotoxic and staining antibody. For staining, use 10 ul/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator. Available Conjugates: This antibody is only available conjugated to Biotin and FITC.
products categories :
MONOCLONAL ANTIBODIES, ANTI-MOUSE LYMPHOCYTES; Monoclonal Antibodies; Anti Mouse Lymphocyte
products description :
Introduction: CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.