catalog number :
MBS140145
products full name :
Mouse Anti Human CD45
products short name :
CD45
products name syn :
CD45 Antibody; CD45, Mouse Anti-Human; Leukocyte common antigen; EC 3.1.3.48; L-CA; T200; CD45 antigen; PTPRC; LCA; LY5; B220; CD45; GP180
other names :
receptor-type tyrosine-protein phosphatase C isoform 1; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; T200; CD_antigen: CD45
products gene name :
CD45
other gene names :
PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA
uniprot entry name :
PTPRC_HUMAN
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
other info2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified human T-Cells. Antibody Properties: Staining antibody. For staining, use 10 ul/1,000,000 cells. Available Conjugates: This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10 ul/106 cells.
products categories :
MONOCLONAL ANTIBODIES, ANTI-HUMAN LYMPHOCYTES; Monoclonal Antibodies; Anti Human Lymphocyte
ncbi acc num :
NP_002829.3
ncbi gb acc num :
NM_002838.4
ncbi mol weight :
130,898 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Axon Guidance Pathway 105688!!B Cell Receptor Signaling Pathway 198909!!BCR Signaling Pathway 138058!!CXCR4-mediated Signaling Events Pathway 137910!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Developmental Biology Pathway 477129!!EPO Receptor Signaling Pathway 198882!!Fc Gamma R-mediated Phagocytosis Pathway 114228
ncbi summary :
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]