catalog number :
MBS140131
products full name :
Mouse Anti Human CD14 Biotinylated
products short name :
CD14 Biotinylated
products name syn :
CD14 Antibody, Biotin; CD14, Mouse Anti-Human Biotin; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD14 Biotin
other names :
NADH dehydrogenase; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH-ubiquinone oxidoreductase subunit CI-B8; complex I B8 subunit; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; Complex I-B8; CI-B8; NADH-ubiquinone oxidoreductase B8 subunit
products gene name :
CD14
other gene names :
NDUFA2; NDUFA2; B8; CD14; CIB8; CI-B8
uniprot entry name :
NDUA2_HUMAN
purity :
Ion exchange column.
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
other info2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified human B Cells. Antibody Properties: For staining, use 10 ul/1,000,000 cells. Available Conjugates: This antibody is also available as purified antibody and conjugated to FITC.
products categories :
MONOCLONAL ANTIBODIES, ANTI-HUMAN LYMPHOCYTES; Monoclonal Antibodies; Anti Human Lymphocyte
products description :
Introduction: CD14 (also known lipopolysaccharide (LPS) receptor) is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 has been shown to bind apoptotic cells.
ncbi acc num :
NP_001171941.1
ncbi gb acc num :
NM_001185012.1
ncbi mol weight :
8,491 Da
ncbi pathways :
Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Electron Transport Chain Pathway 198860!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!NADH Dehydrogenase (ubiquinone) 1 Alpha Subcomplex Pathway 413408!!NADH Dehydrogenase (ubiquinone) 1 Alpha Subcomplex Pathway 890443!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188
ncbi summary :
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]