Mouse Anti Neisseria Gonorrhea | MyBioSource MBS140079 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Neisseria Gonorrhea

catalog :

MBS140079

quantity :

0.5 mg

price :

230 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NYRGon

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140079

products type :

Antibody

products full name :

Mouse Anti Neisseria Gonorrhea

products short name :

Neisseria Gonorrhea

products name syn :

Gonorrhea Antibody; Neisseria Gonorrhea, Mouse Antibody; Gonorrhea

other names :

angiogenin; Angiogenin; angiogenin; RNase 5; epididymis luminal protein 168; ribonuclease 5; ribonuclease A A1; angiogenin, ribonuclease, RNase A family, 5; Ribonuclease 5; RNase 5

other gene names :

ANG; ANG; ALS9; RAA1; HEL168; RNASE4; RNASE5; RNASE5; RNase 5

uniprot entry name :

ANGI_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

NYRGon

host :

Mouse

sequence length :

147

purity :

Ion exchange column.

concentration :

1mg/ml in PBS (after reconstitution).

storage stability :

In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.

tested application :

ELISA (EIA)

app notes :

By direct ELISA,1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories.

other info2 :

Reconstitution: Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: purified ns envelop.

products categories :

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

products description :

Introduction: Neisseria gonorrhoeae, also known as Gonococci is a Gram-negativebacteriahighly fastidiouscocci, requiring nutrient supplementation to survive. The cocci are facultatively intracellular and typically appear in pairs (diplococci). Neisserial LPS is distinguished from enteric LPS by its highly-branched basal oligosaccharide structure and the absence of repeating O-antigen subunits. For these reasons, neisserial LPS is referred to as lipooligosaccharide (LOS). The bacterium characteristically releases outer membrane fragments called "blebs" during growth. These blebs contain LOS and probably have a role in pathogenesis if they are disseminated during the course of an infection. Neisseria gonorrhoeae is a relatively fragile organism, susceptible to temperature changes, drying, uv light, and other environmental conditions. Strains of N. gonorrhoeae are variable in their cultural requirements so that media containing hemoglobin, NAD, yeast extract and other supplements are needed for isolation and growth of the organism.

ncbi gi num :

148277046

ncbi acc num :

NP_001091046.1

ncbi gb acc num :

NM_001097577.2

ncbi mol weight :

16,550 Da

ncbi summary :

The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]

uniprot summary :

ANG: May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. Belongs to the pancreatic ribonuclease family. Protein type: EC 3.1.27.-; Nucleolus; Secreted; Cell cycle regulation; Extracellular matrix; Ribonuclease; Secreted, signal peptide; Motility/polarity/chemotaxis; RNA-binding. Chromosomal Location of Human Ortholog: 14q11.1-q11.2. Cellular Component: extracellular space; angiogenin-PRI complex; growth cone; cell soma; nucleolus; basal lamina; nucleus. Molecular Function: heparin binding; rRNA binding; protein binding; copper ion binding; DNA binding; endonuclease activity; actin binding; peptide binding; ribonuclease activity; receptor binding. Biological Process: cell migration; diacylglycerol biosynthetic process; negative regulation of smooth muscle cell proliferation; activation of protein kinase B; response to hormone stimulus; activation of phospholipase A2; oocyte maturation; rRNA transcription; ovarian follicle development; homeostatic process; positive regulation of protein secretion; actin filament polymerization; phospholipase C activation; negative regulation of translation; response to hypoxia; positive regulation of endothelial cell proliferation; cell communication; angiogenesis; positive regulation of phosphorylation; placenta development. Disease: Amyotrophic Lateral Sclerosis 9

size1 :

0.5 mg

price1 :

230 USD

size2 :

1 mg

price2 :

350

more info or order :

MyBioSource product webpage