Mouse Anti Human Transforming Growth Factor-beta | MyBioSource MBS140064 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Transforming Growth Factor-beta

catalog :

MBS140064

quantity :

0.5 mg

price :

230 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

hTGF-b

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140064

products type :

Antibody

products full name :

Mouse Anti Human Transforming Growth Factor-beta

products short name :

Transforming Growth Factor-beta

products name syn :

TGF b Antibody; Transforming Growth Factor-beta, Mouse-Anti Human; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3

other names :

bone morphogenetic protein 7; Bone morphogenetic protein 7; bone morphogenetic protein 7; osteogenic protein 1; bone morphogenetic protein 7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa

products gene name :

TGFB

other gene names :

BMP7; BMP7; OP-1; OP1; BMP-7; OP-1

uniprot entry name :

BMP7_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

hTGF-b

host :

Mouse

sequence length :

431

purity :

Ion exchange column.

concentration :

1mg/ml in PBS (after reconstitution).

storage stability :

Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.

tested application :

ELISA (EIA)

app notes :

In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson ImmunoResearch Laboratories) 1:10,000 dilution will yield 0.7 O.D within 10 minutes.

other info2 :

Reconstitution: Reconstitute with 0.5ml H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Note: This antibody will bind very well to protein A in a buffer (PBS) containing high salt concentration (3M Nacl). Immunogen: r.Human TGF-b.

products categories :

ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

products description :

Introduction: Transforming growth factor betas (TGFBetas) mediate many cell-cell interactions that occur during embryonic development. Three TGFBetas have been identified in mammals. TGFBeta1, TGFBeta2 and TGFBeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. This antibody reacts with the precursor and mature form of TGFBeta2 and to a lesser extent TGFBeta3, but does not cross react with TGFBeta1.

ncbi gi num :

4502427

ncbi acc num :

NP_001710.1

ncbi gb acc num :

NM_001719.2

ncbi mol weight :

49,313 Da

ncbi pathways :

ALK2 Signaling Events Pathway (137983); BMP Receptor Signaling Pathway (137948); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Hippo Signaling Pathway (749777)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20q13. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: negative regulation of MAP kinase activity; axon guidance; response to peptide hormone stimulus; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; negative regulation of phosphorylation; negative regulation of Notch signaling pathway; epithelial to mesenchymal transition; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth

size1 :

0.5 mg

price1 :

230 USD

size2 :

1 mg

price2 :

350

more info or order :

MyBioSource product webpage