antibody

Rat Anti Mouse IFN-gamma

MBS140062

0.5 mg

230 USD

monoclonal

rat

nonconjugated

NYRmIFNg

western blot, ELISA, immunoprecipitation, enzyme immunoassay

Antibody

Rat Anti Mouse IFN-gamma

IFN-gamma

IFN g Antibody; Interferon-gamma, Rat Anti-Mouse; Immune Interferon; type II interferon; T cell interferon; MAF; IFNG; IFG; IFI; IFN-gamma

interferon gamma; Interferon gamma; interferon gamma; IFN-gamma; gamma interferon; interferon gamma

IFN-g

Ifng; Ifng; Ifg; IFN-g; IFN-gamma

IFNG_MOUSE

Monoclonal

IgG1

NYRmIFNg

Rat

155

Ion exchange

1mg/ml in PBS (after reconstitution).

In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Intracellular Staining

Direct ELISA, Western Blot, Immunoprecipitation, Intracellular staining. By direct ELISA, 1:8,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.

Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: r.mouse IFN-g.

MONOCLONAL ANTIBODIES, ANTI-MOUSE CYTOKINE; Monoclonal Antibodies; Anti Mouse Cytokine

Introduction: IFN-gamma produced by lymphocytes activated by specific antigens or mitogens.IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

33468859

NP_032363.1

NM_008337.3

17,907 Da

African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (83316); Allograft Rejection Pathway (535); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Antigen Processing And Presentation Pathway (83271); Antigen Processing And Presentation Pathway (485); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795)

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]

IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. Protein type: Secreted, signal peptide; Secreted; Cytokine; Membrane protein, integral. Cellular Component: extracellular space; cell; extracellular region; intracellular; external side of plasma membrane. Molecular Function: protein binding; interferon-gamma receptor binding; cytokine activity. Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of cell adhesion; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; positive regulation of interleukin-1 beta secretion; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; regulation of growth; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; negative regulation of myelination; CD8-positive, alpha-beta T cell differentiation during immune response; response to virus; positive regulation of tumor necrosis factor production; defense response to protozoan; inflammatory cell apoptosis; positive regulation of tyrosine phosphorylation of Stat1 protein; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-12 production; negative regulation of smooth muscle cell proliferation; apoptosis; positive regulation of interleukin-6 biosynthetic process; sensory perception of mechanical stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; adaptive immune response; regulation of immune response; unfolded protein response; humoral immune response; antigen processing and presentation; positive regulation of interleukin-12 biosynthetic process; negative regulation of interleukin-17 production; positive regulation of chemokine biosynthetic process; protein import into nucleus, translocation; immune response; positive regulation of neuron differentiation; regulation of insulin secretion

0.5 mg

230 USD

1 mg

350