product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rat Anti Mouse B220 (CD45R)
catalog :
MBS140040
quantity :
0.5 mg
price :
230 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
mB220
reactivity :
Saccharomyces cerevisiae S288c
more info or order :
product information
catalog number :
MBS140040
products type :
Antibody
products full name :
Rat Anti Mouse B220 (CD45R)
products short name :
B220
products name syn :
B220 Antibody; B220 (B cell specific isoform of CD45), Rat Anti-Mouse; LCA; PTPRC; LY5; B220; CD45R; T200; GP180; PROTEIN-TYROSINE PHOSPHATASE; RECEPTOR-TYPE C
other names :
DNA-directed RNA polymerase II core subunit RPO21; DNA-directed RNA polymerase II core subunit RPO21
products gene name :
B220
other gene names :
RPO21; RPB1; RPB220; SUA8
clonality :
Monoclonal
isotype :
IgM
clone :
mB220
host :
Rat
sequence length :
1733
purity :
Ion exchange column.
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
other info2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified mouse LN B cells. Antibody Properties: Staining antibody. For staining, use 10 ul/1,000,000 cells. Available Conjugates: This antibody is only available as purified antibody.
products categories :
MONOCLONAL ANTIBODIES, ANTI-MOUSE LYMPHOCYTES; Monoclonal Antibodies; Anti Mouse Lymphocyte
products description :
Introduction: B220 (CD45R) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.B220 (CD45R) is required for t-cell activation through the antigen receptor. The first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
ncbi gi num :
6320061
ncbi acc num :
NP_010141.1
ncbi gb acc num :
NM_001180200.1
ncbi pathways :
Eukaryotic Transcription Initiation Pathway 198636!!Metabolic Pathways 131993!!Purine Metabolism Pathway 870!!Purine Metabolism Pathway 307!!Pyrimidine Metabolism Pathway 871!!Pyrimidine Metabolism Pathway 309!!RNA Polymerase Pathway 946!!RNA Polymerase Pathway 442!!RNA Polymerase II, Eukaryotes Pathway 438660!!RNA Polymerase II, Eukaryotes Pathway 890456
size :
0.5 mg
price :
230 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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