catalog number :
MBS140037
products full name :
Rat Anti Mouse CD11b FITC
products short name :
CD11b
products name syn :
CD11b FITC Antibody; CD11b FITC, Rat Anti-Mouse; Integrin; alpha M; CR3A; MO1A; CD11B; MAC-1; MAC1A; MGC117044; ITGAM TypeRat Anti Mouse Monoclonal; CD11b FITC
other names :
CD11b, partial; CD11b; integrin alpha-M; CD11b
products gene name :
CD11b
other gene names :
ITGAM; CD11b; CD11B
uniprot entry name :
Q28984_PIG
purity :
Ion exchange column.
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
other info2 :
Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: Purified mouse LN CD4+ T cells. Antibody Properties: Staining and blocking antibody. For staining, use 10 ul/1,000,000 cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator. Available Conjugates: This antibody is only available conjugated to FITC.
products categories :
MONOCLONAL ANTIBODIES, ANTI-MOUSE LYMPHOCYTES; Monoclonal Antibodies; Anti Mouse Lymphocyte
products description :
Introduction: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain.
ncbi acc num :
AAB16869.1
ncbi mol weight :
102,441 Da
ncbi pathways :
Amoebiasis Pathway 167313!!Amoebiasis Pathway 167191!!Cell Adhesion Molecules (CAMs) Pathway 84481!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 1124973!!Extracellular Matrix Organization Pathway 1125418!!Hematopoietic Cell Lineage Pathway 84490!!Hematopoietic Cell Lineage Pathway 489!!Hemostasis Pathway 1124941!!Immune System Pathway 1125064