catalog number :
MBS140021
products full name :
Mouse Anti Human Macrophage/Monocyte Chemotactic Protein-3/MARC
products short name :
Macrophage/Monocyte Chemotactic Protein-3/MARC
products name syn :
MCP 3 Antibody; Macrophage/Monocyte Chemotactic Protein-3/MARC, Mouse Anti-Human; Small inducible cytokine A7; CCL7; Monocyte chemotactic protein 3; MCP-3; Monocyte chemoattractant protein 3; NC28; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; SCYA6; SCYA7; MGC138463; MGC138465
other names :
C-C motif chemokine 7; C-C motif chemokine 7; C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7; chemokine (C-C motif) ligand 7; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7
products gene name :
MCP-3
other gene names :
CCL7; CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MCP3; SCYA6; SCYA7; MCP-3
uniprot entry name :
CCL7_HUMAN
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.
tested application :
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
app notes :
Direct ELISA, Western Blot, Immunoprecipitation. In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:20,000 dilution will give 0.2 O.D.
other info2 :
Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: r.Human MCP-3.
products categories :
MONOCLONAL ANTIBODIES, ANTI-HUMAN CHEMOKINES; Monoclonal Antibodies; Anti Human Chemokine
products description :
Introduction: Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophagefunction. It is produced by certain tumor celllines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1).
ncbi acc num :
NP_006264.2
ncbi gb acc num :
NM_006273.3
ncbi mol weight :
11,200 Da
ncbi pathways :
Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!GPCR Ligand Binding Pathway 161020!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637
ncbi summary :
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]