Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor | MyBioSource MBS140020 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor

catalog :

MBS140020

quantity :

0.5 mg

price :

230 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

YNR-HMCAF

reactivity :

human

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140020

products type :

Antibody

products full name :

Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor

products short name :

Macrophage/Monocyte Chemotactic & Activating Factor

products name syn :

MCP 1 Antibody; Macrophage/Monocyte Chemotactic & Activating Factor, Mouse Anti-Human; Small inducible cytokine A2; CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11; chemokine (C-C motif) ligand 2; MCP1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; GDCF-2 HC11

other names :

C-C motif chemokine 2; C-C motif chemokine 2; C-C motif chemokine 2; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2; chemokine (C-C motif) ligand 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2

products gene name :

MCP-1

other gene names :

CCL2; CCL2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MCP1; SCYA2; MCAF; MCP-1

uniprot entry name :

CCL2_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

YNR-HMCAF

host :

Mouse

sequence length :

purity :

Ion exchange

concentration :

1mg/ml in PBS (after reconstitution) Shipping ConditionsAntibody is shipped lyophilized at ambient temperature.

storage stability :

In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.

tested application :

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

app notes :

Direct ELISA, Western Blot, Immunoprecipitation. In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:5,000 dilution will give 0.3 O.D within 10 minutes.

other info2 :

Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Note: MCAF does not bind to plastic as good as most proteins - use higher concentration for proper binding. Immunogen: r.Human MCAF.

products categories :

MONOCLONAL ANTIBODIES, ANTI-HUMAN CHEMOKINES; Monoclonal Antibodies; Anti Human Chemokine

products description :

Introduction: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B (NF?B). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

ncbi gi num :

4506841

ncbi acc num :

NP_002973.1

ncbi gb acc num :

NM_002982.3

ncbi mol weight :

11,025 Da

ncbi pathways :

ATF4 Activates Genes Pathway 530772!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664

ncbi summary :

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

size :

0.5 mg

price :

230 USD

more info or order :

MyBioSource product webpage