catalog number :
MBS140016
products full name :
Mouse Anti Human Interleukin-15
products short name :
Interleukin-15
products name syn :
IL 15 Antibody; Interleukin-15, Mouse Anti-Human; IL-15; MGC9721
other names :
interleukin-15; Interleukin-15; interleukin-15; IL-15; interleukin 15
products gene name :
IL-15
other gene names :
Il15; Il15; IL-15
uniprot entry name :
IL15_RAT
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.
tested application :
ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC)
app notes :
Direct ELISA, Immunoprecipitation, Immunohistochemistry. By direct ELISA, 1:20,000 dilution will yield >1.0 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.
other info2 :
Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: r.Human IL-15.
products categories :
ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
products description :
Introduction: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
ncbi acc num :
NP_037261.1
ncbi gb acc num :
NM_013129.2
ncbi mol weight :
17,025 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83443); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response (BioCarta) Pathway (198521); HTLV-I Infection Pathway (373894); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377869); Herpes Simplex Infection Pathway (377865); Intestinal Immune Network For IgA Production Pathway (128752); Intestinal Immune Network For IgA Production Pathway (128670); Jak-STAT Signaling Pathway (83469)
ncbi summary :
human homolog is a cytokine involved in the regulation of T and natural killer cell activation and proliferation [RGD, Feb 2006]