Mouse Anti Human Interleukin-7 | MyBioSource MBS140011 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Interleukin-7

catalog :

MBS140011

quantity :

0.5 mg

price :

230 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NYRhIL7

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140011

products type :

Antibody

products full name :

Mouse Anti Human Interleukin-7

products short name :

Interleukin-7

products name syn :

IL 7 Antibody; Interleukin-7, Mouse Anti-Human; Lymphopoietin 1 (LP-1); pre-B cell factor; IL-7 TypeMouse Anti Human Monoclonal

other names :

interleukin-7 isoform 1; Interleukin-7; interleukin-7; interleukin 7

products gene name :

IL-7

other gene names :

IL7; IL7; IL-7; IL-7

uniprot entry name :

IL7_HUMAN

isotype :

IgG1

clone :

NYRhIL7

host :

Mouse

sequence length :

177

purity :

Ion exchange

concentration :

1mg/ml in PBS (after reconstitution).

storage stability :

In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature.

tested application :

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Intracellular Staining

app notes :

Direct ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Intracellular staining. By direct ELISA, 1:10,000 dilution will yield 0.3 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.

other info2 :

Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Immunogen: r.Human IL-7.

products categories :

ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

products description :

Introduction: IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

ncbi gi num :

4504677

ncbi acc num :

NP_000871.1

ncbi gb acc num :

NM_000880.3

ncbi mol weight :

7,687 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Interleukin-7 Signaling Pathway (530762); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); PI3K-Akt Signaling Pathway (692234)

ncbi summary :

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

uniprot summary :

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell development/differentiation; Cell cycle regulation; Secreted, signal peptide; Secreted; Apoptosis; Cytokine. Chromosomal Location of Human Ortholog: 8q12-q13. Cellular Component: extracellular space; extracellular region. Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity. Biological Process: organ morphogenesis; T cell lineage commitment; cell-cell signaling; positive regulation of T cell differentiation; regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of organ growth; humoral immune response; bone resorption; negative regulation of apoptosis

size1 :

0.5 mg

price1 :

230 USD

size2 :

1 mg

price2 :

350

more info or order :

MyBioSource product webpage