Recombinant Human Optineurin (OPTN) | MyBioSource MBS1399122 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Optineurin (OPTN)

catalog :

MBS1399122

quantity :

0.01 mg (E-Coli)

price :

200 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS1399122

products type :

Recombinant Protein

products full name :

Recombinant Human Optineurin (OPTN)

products short name :

[Optineurin (OPTN)]

other names :

[optineurin; Optineurin; optineurin; optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP]

products gene name :

[OPTN]

products gene name syn :

[OPTN]

other gene names :

[OPTN; OPTN; NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP; FIP2; GLC1E; HIP7; HYPL; NRP; HIP-7; TFIIIA-IntP]

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

[1-577aa; Full Length]

sequence length :

577

sequence :

MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEE
LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEK
QKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGK
SERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKAD
LLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEI
KHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVS
QLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSE
IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKE
LQEAHTKLSKAELMKKRLQEKCQALERKNSAIPSELNEK
QELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQ
MTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEK
LELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQM
EVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFE
DGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQ
QRNIPIHSCPKCGEVLPDIDTLQIHVMDCII

purity :

>85% (SDS-PAGE)

form :

Liquid containing glycerol

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

image1 heading :

SDS-Page

other info1 :

Species: Human

other info2 :

Storage Buffer: Tris-based buffer, 50% glycerol. Production Note: Special Offer: The Baculovirus, E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. Baculovirus, E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Baculovirus, E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Baculovirus, E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

products description :

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

ncbi gi num :

56549107

ncbi acc num :

NP_001008212.1

ncbi gb acc num :

NM_001008211.1

uniprot acc num :

Q96CV9

ncbi mol weight :

59,559 Da

ncbi pathways :

Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); G2/M Transition Pathway (1269799); Mitotic G2-G2/M Phases Pathway (1269797); Regulation Of PLK1 Activity At G2/M Transition Pathway (1269803)

ncbi summary :

uniprot summary :

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.

size1 :

0.01 mg (E-Coli)

price1 :

200 USD

size2 :

0.01 mg (Baculovirus)

price2 :

235

size3 :

0.05 mg (E-Coli)

price3 :

260

size4 :

0.02 mg (Baculovirus)

price4 :

355

size5 :

0.1 mg (E-Coli)

price5 :

430

size6 :

0.05 mg (Baculovirus)

price6 :

680

size7 :

0.2 mg (E-Coli)

price7 :

685

size8 :

0.1 mg (Baculovirus)

price8 :

940

size9 :

0.5 mg (E-Coli)

price9 :

1125

size10 :

0.5 mg (Baculovirus)

price10 :

1325

size11 :

1 mg (E-Coli)

price11 :

1725

size12 :

1 mg (Baculovirus)

price12 :

1845

more info or order :

MyBioSource product webpage