catalog number :
MBS1394153
products type :
Recombinant Protein
products full name :
Recombinant Human Lysyl oxidase homolog 4 (LOXL4)
products short name :
[Lysyl oxidase homolog 4 (LOXL4)]
products name syn :
[Lysyl oxidase homolog 4; EC=1.4.3.-; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C]
other names :
[lysyl oxidase homolog 4; Lysyl oxidase homolog 4; lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like protein 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-related protein C; lysyl oxidase-like 4; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C]
products gene name :
[LOXL4]
products gene name syn :
[LOXL4; LOXC]
other gene names :
[LOXL4; LOXL4; LOXC; LOXC]
uniprot entry name :
LOXL4_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[25-756aa; Full Length]
sequence :
QSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDDNFA
IQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRC
VGTESSLDQCGSNGWGVSDCSHSEDVGVICHPRRHRGYL
SETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVE
VKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHY
YRKVWDLKMRDPKSRLKSLTNKNSFWIHQVTCLGTEPHM
ANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKT
KPQRKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVC
DHRWNLISASVVCRQLGFGSAREALFGARLGQGLGPIHL
SEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPN
MGFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSEN
WGLTEAMVACRQLGLGFAIHAYKETWFWSGTPRAQEVVM
SGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDS
APDLVMNAQLVQETAYLEDRPLSQLYCAHEENCLSKSAD
HMDWPYGYRRLLRFSTQIYNLGRTDFRPKTGRDSWVWHQ
CHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNC
PTGLQRRYACANFGEQGVTVGCWDTYRHDIDCQWVDITD
VGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRV
WLHNCHTGNSYPANAELSLEQEQRLRNNLI
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
image1 heading :
SDS-PAGE
other info1 :
Species: Homo sapiens (Human)
products categories :
Signal Transduction
products description :
May modulate the formation of a collagenous Extracellular domain matrix.
ncbi acc num :
NP_115587.6
ncbi gb acc num :
NM_032211.6
ncbi mol weight :
84,483 Da
ncbi pathways :
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Crosslinking Of Collagen Fibrils Pathway (730308); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262)
ncbi summary :
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
uniprot summary :
LOXL4: May modulate the formation of a collagenous extracellular matrix. Belongs to the lysyl oxidase family. Protein type: Oxidoreductase; EC 1.4.3.-; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q24. Cellular Component: extracellular space; membrane; receptor complex. Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity; scavenger receptor activity. Biological Process: receptor-mediated endocytosis