catalog number :
MBS1391552
products type :
Recombinant Protein
products full name :
Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein
products short name :
Endogenous retrovirus group K member 6 Env polyprotein
products name syn :
EnvK2 protein; Envelope polyprotein; HERV-K(C7) envelope protein; HERV-K(HML-2.HOM) envelope protein; HERV-K108 envelope protein;HERV-K_7p22.1 provirus ancestral Env polyprotein; Cleaved into the following 2 chains: Surface proten; SU; Transmembrane protein; TM
other names :
Endogenous retrovirus group K member 6 Env polyprotein; Endogenous retrovirus group K member 6 Env polyprotein; EnvK2 protein; Envelope polyprotein; HERV-K(C7) envelope protein; HERV-K(HML-2.HOM) envelope protein; HERV-K108 envelope protein; HERV-K_7p22.1 provirus ancestral Env polyprotein
products gene name :
ERVK-6
other gene names :
ERVK-6; ERVK6; SU; TM
uniprot entry name :
ENK6_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
90-632, Fragment at the N-terminal, provide the complete extracellular domain.
sequence :
LPMPAGAAAANYTYWAYVPFPPLIRAVTWMDNPTEVYVN
DSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGR
APGCLMPAVQNWLVEVPTVSPICRFTYHMVSGMSLRPRV
NYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEE
CVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPS
AQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGISTP
RPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRD
RKPFYTIDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQ
TITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMD
RPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIA
VTATAAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSI
DQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSD
FCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQ
IFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKT
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products description :
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.
SU mediates receptor recognition.
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane
products references :
Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K."
Loewer R., Toenjes R.R., Korbmacher C., Kurth R., Loewer J.
J. Virol. 69:141-149(1995)
ncbi mol weight :
77.44kD
uniprot summary :
ERVK6: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily. Protein type: Protease; EC 3.1.26.4; Ribonuclease; Membrane protein, integral; EC 2.7.7.7; EC 3.4.23.16; EC 2.7.7.49; EC 3.4.23.-; Transferase. Chromosomal Location of Human Ortholog: 7p22.1