catalog number :
MBS1389443
products type :
Recombinant Protein
products full name :
Recombinant Human Hereditary hemochromatosis protein (HFE), partial
products short name :
[Hereditary hemochromatosis protein (HFE)]
other names :
[hereditary hemochromatosis protein isoform 1; Hereditary hemochromatosis protein; hereditary hemochromatosis protein; homeostatic iron regulator; HLA-H]
products gene name :
[HFE]
products gene name syn :
[HFE]
other gene names :
[HFE; HFE; HH; HFE1; HLA-H; MVCD7; TFQTL2; HLAH]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[23-306aa; Extracellular Domain]
sequence :
RLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFY
DHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTV
DFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYG
YDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQ
NRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVT
SSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDV
LPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIV
IWEPSPSGTLV
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
image1 heading :
SDS-Page
other info1 :
Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol. Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ncbi acc num :
NP_000401.1
ncbi gb acc num :
NM_000410.3
ncbi mol weight :
8,208 Da
ncbi summary :
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.