product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Oligodendrocyte transcription factor 2
catalog :
MBS1371789
quantity :
0.01 mg (E-Coli)
price :
110 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1371789
products type :
Recombinant Protein
products full name :
Recombinant Human Oligodendrocyte transcription factor 2
products short name :
Oligodendrocyte transcription factor 2
products name syn :
Class B basic helix-loop-helix protein 1; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
other names :
oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte transcription factor 2; oligodendrocyte lineage transcription factor 2; Class B basic helix-loop-helix protein 1; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
products gene name :
OLIG2
other gene names :
OLIG2; OLIG2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19; BHLHB1; BHLHE19; PRKCBP2; RACK17; Oligo2; bHLHb1; bHLHe19
uniprot entry name :
OLIG2_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-323
sequence length :
323
sequence :
MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTV
SSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSS
SSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRE
RKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLAR
NYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHS
APLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAA
AAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLG
GGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGA
GSLPRLTSDAK
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Homo sapiens (Human)
products categories :
Epigenetics and Nuclear Signaling
products description :
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the emembryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development
products references :
Protein kinase C-binding protein." Kuroda S., Tokunaga C., Kiyohara Y., Konishi H., Kikkawa U. Submitted (FEB-1996)
ncbi gi num :
17978475
ncbi acc num :
NP_005797.1
ncbi gb acc num :
NM_005806.3
uniprot acc num :
Q13516
ncbi mol weight :
48.36kD
ncbi pathways :
Neural Crest Differentiation Pathway (672460)
ncbi summary :
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
uniprot summary :
OLIG2: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. Protein type: Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: cytoplasm; nucleus. Molecular Function: DNA binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding. Biological Process: myelination; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; positive regulation of oligodendrocyte differentiation; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell fate specification; thalamus development; transcription, DNA-dependent
size1 :
0.01 mg (E-Coli)
price1 :
110 USD
size2 :
0.05 mg (E-Coli)
price2 :
190
size3 :
0.02 mg (Mammalian-Cell)
price3 :
295
size4 :
0.2 mg (E-Coli)
price4 :
460
size5 :
0.05 mg (Mammalian-Cell)
price5 :
575
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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