Recombinant Human Centromere protein U (MLF1IP) | MyBioSource MBS1364641 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Centromere protein U (MLF1IP)

catalog :

MBS1364641

quantity :

0.5 mg (E-Coli)

price :

1195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1364641

products type :

Recombinant Protein

products full name :

Recombinant Human Centromere protein U (MLF1IP)

products short name :

Centromere protein U (MLF1IP)

products name syn :

Centromere protein U; CENP-U; Interphase centromere complex protein 24; KSHV latent nuclear antigen-interacting protein 1; MLF1-interacting protein; Polo-box-interacting protein 1; centromere protein of 50 kDa; CENP-50

other names :

centromere protein U; Centromere protein U; centromere protein U; MLF1 interacting protein; MLF1-interacting protein; centromere protein of 50 kDa; polo-box-interacting protein 1; interphase centromere complex protein 24; KSHV latent nuclear antigen interacting protein 1; KSHV latent nuclear antigen-interacting protein 1; centromere protein U; Centromere protein of 50 kDa; CENP-50; Interphase centromere complex protein 24; KSHV latent nuclear antigen-interacting protein 1; MLF1-interacting protein; Polo-box-interacting protein 1

products gene name :

MLF1IP

products gene name syn :

MLF1IP; CENPU; ICEN24; KLIP1; PBIP1

other gene names :

CENPU; CENPU; KLIP1; PBIP1; CENP50; MLF1IP; CENPU50; ICEN24; KLIP1; MLF1IP; PBIP1; CENP-U; CENP-50

uniprot entry name :

CENPU_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-418

sequence length :

418

sequence :

MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA ESHLRNINHQ LEKLLDQG

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

ncbi gi num :

38016935

ncbi acc num :

NP_078905.2

ncbi gb acc num :

NM_024629.3

uniprot acc num :

Q71F23

ncbi mol weight :

61kD

ncbi pathways :

Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Chromosome Maintenance Pathway (161048); Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway (161050); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818); Mitotic Metaphase And Anaphase Pathway (730317); Mitotic Prometaphase Pathway (105815); Nucleosome Assembly Pathway (161049); PLK1 Signaling Events Pathway (138007)

ncbi summary :

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

uniprot summary :

CENPU: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 4q35.1. Cellular Component: nucleoplasm; microtubule organizing center; cytosol; nucleus. Biological Process: nucleosome assembly; chordate embryonic development; DNA replication-independent nucleosome assembly at centromere; transcription, DNA-dependent; regulation of transcription, DNA-dependent; viral reproduction; mitotic cell cycle

size1 :

0.5 mg (E-Coli)

price1 :

1195 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1195

size3 :

0.5 mg (Yeast)

price3 :

1415

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1415

size5 :

1 mg (E-Coli)

price5 :

1920

more info or order :

MyBioSource product webpage