Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 | MyBioSource MBS1359962 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5

catalog :

MBS1359962

quantity :

0.01 mg (E-Coli)

price :

135 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1359962

products type :

Recombinant Protein

products full name :

Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5

products short name :

1-acylglycerol-3-phosphate O-acyltransferase ABHD5

products name syn :

Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58

other names :

1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain containing 5; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58

products gene name :

ABHD5

other gene names :

ABHD5; ABHD5; CDS; CGI58; IECN2; NCIE2; NCIE2

uniprot entry name :

ABHD5_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

2-349

sequence length :

349

sequence :

AAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEE
KMLKCVPCTYKKEPVRISNGNKIWTLKFSHNISNKTPLV
LLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRP
RFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGF
LAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPV
WIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRK
YSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAK
RPMLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRP
HSYVKTIAILGAGHYVYADQPEEFNQKVKEICDTVD

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

other info2 :

Species: Homo sapiens (Human)

products categories :

Cancer

products description :

Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation.

products references :

Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome." Lefevre C., Jobard F., Caux F., Bouadjar B., Karaduman A., Heilig R., Lakhdar H., Wollenberg A., Verret J.-L., Weissenbach J., Oezguec M., Lathrop M., Prud'homme J.-F., Fischer J. Am. J. Hum. Genet. 69:1002-1012(2001)

ncbi gi num :

31542303

ncbi acc num :

NP_057090.2

ncbi gb acc num :

NM_016006.4

uniprot acc num :

Q8WTS1

ncbi mol weight :

54.94kD

ncbi pathways :

CDP-diacylglycerol Biosynthesis Pathway (142255); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (1270009); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Regulation Of Lipolysis In Adipocytes Pathway (1222950); Triacylglycerol Biosynthesis Pathway (142242)

ncbi summary :

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]

uniprot summary :

ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons. Protein type: Transferase; EC 2.3.1.51; Lipase. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particle; nucleus. Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity; triacylglycerol lipase activity. Biological Process: cell differentiation; fatty acid metabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity; sequestering of lipid; triacylglycerol catabolic process. Disease: Chanarin-dorfman Syndrome

size1 :

0.01 mg (E-Coli)

price1 :

135 USD

size2 :

0.05 mg (E-Coli)

price2 :

255

size3 :

0.2 mg (E-Coli)

price3 :

665

size4 :

0.5 mg (E-Coli)

price4 :

1090

size5 :

0.05 mg (Baculovirus)

price5 :

1115

more info or order :

MyBioSource product webpage