protein

Apolipoprotein H, Human Plasma

MBS135988

0.1 mg

400 USD

Native Protein

Apolipoprotein H, Human Plasma

[Apolipoprotein H]

[beta-2-glycoprotein 1; Beta-2-glycoprotein 1; beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; apolipoprotein H (beta-2-glycoprotein I); APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI]

[APOH; APOH; BG; B2G1; B2GP1; B2G1; Apo-H; B2GPI; Beta(2)GPI]

APOH_HUMAN

Human Plasma

345

>95% by SDS-PAGE analysis

Frozen liquid; 0.02M EPPs; 0.15M NaCl; pH 8.0

1.65 mg/ml

Store at -70 degree C; Shipping: Dry ice

Extinction Coefficient: 0.94

HUMAN PLASMA PROTEINS

Apolipoprotein H, also known as beta2Glycoprotein-1 (B2GP-1) is a plasma glycoprotein that circulates at a concentration of 200 ug/mL (4mM). B2GP-1 has been identified as a constituent of chylomicrons, very low density lipoproteins and high density lipoproteins in Human plasma. It has also been demonstrated to bind phospholipids, heparin and platelets where it can modulate the activity of adenylate (19percent). Although the precise function(s) are as yet unknown, B2GP-1 has been shown to interfere with blood coagulation by competitively binding to phospholipids exposed during cell activation or damage. Recent evidence also implicates B2GP-1 as a cofactor recognized by some anti-phospholipid antibodies present in autoimmune disorders such as systemic lupus erythematosus (SLE).

153266841

NP_000033.2

NM_000042.2

P02749

48000

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Protein type: Secreted; Secreted, signal peptide; Lipid-binding. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface. Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding. Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; negative regulation of fibrinolysis; triacylglycerol metabolic process; positive regulation of blood coagulation; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis

0.1 mg

400 USD

0.5 mg

1480