Recombinant Mouse Coagulation Factor XIIa | MyBioSource MBS135876 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Coagulation Factor XIIa

catalog :

MBS135876

quantity :

0.05 mg

price :

440 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135876

products type :

Recombinant Protein

products full name :

Recombinant Mouse Coagulation Factor XIIa

products short name :

Coagulation Factor XIIa

other names :

coagulation factor XII; Coagulation factor XII; coagulation factor XII; hageman factor; coagulation factor XII (Hageman factor); Hageman factor

products gene name :

F12

other gene names :

F12; F12; HAF; FXII; HAF

uniprot entry name :

FA12_MOUSE

host :

Insect cell culture

sequence length :

597

purity :

>95% by SDS-PAGE analysis

form :

Frozen liquid

concentration :

1.1 mg/ml

storage stability :

Store at -70 degree C. Shelf Life: 3 years from delivery

other info1 :

Aliquot: 1 x 0.05mg. Volume: 0.045 ml

other info2 :

Buffer: 4 mM Sodium Acetate; 0.15 M NaCl; pH 5.3. Extinction Coefficient: 1.73

products categories :

Factor XII; Mouse Factor XIIa

products description :

Mouse Factor alpha-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system of blood coagulation. Recombinant insect cell derived mouse Factor alpha-XIIa is manufactured by autoactivation of recombinant mouse Factor XII with Dextran Sulfate and re-purifed to remove the activator. >95 percent activation is observed on SDS-PAGE. The protein purity is determined by SDS-PAGE and activity is determined via complementation in a APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for details.

ncbi gi num :

171906584

ncbi acc num :

NP_067464.2

ncbi gb acc num :

NM_021489.2

uniprot acc num :

Q80YC5

ncbi mol weight :

75,000 (Approximate)

ncbi pathways :

Blood Clotting Cascade Pathway (198388); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (765583); Hemostasis Pathway (765555); Intrinsic Pathway (765585)

ncbi summary :

This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]

uniprot summary :

F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family. Protein type: Protease; Secreted; Chaperone; EC 3.4.21.38; Secreted, signal peptide. Cellular Component: extracellular space; extracellular region. Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity. Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; hemostasis; plasma kallikrein-kinin cascade; regulation of blood coagulation; positive regulation of fibrinolysis; zymogen activation; protein processing; blood coagulation; Factor XII activation

size1 :

0.05 mg

price1 :

440 USD

size2 :

0.1 mg

price2 :

625

more info or order :

MyBioSource product webpage