Human Protein C | MyBioSource MBS135843 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Protein C

catalog :

MBS135843

quantity :

0.1 mg

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135843

products type :

Protein

products full name :

Human Protein C

products short name :

[Human Protein C]

other names :

[vitamin K-dependent protein C preproprotein; Vitamin K-dependent protein C; vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV; protein C (inactivator of coagulation factors Va and VIIIa); Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV]

products gene name :

[PROC]

other gene names :

[PROC; PROC; PC; APC; PROC1; THPH3; THPH4]

uniprot entry name :

PROC_HUMAN

host :

Human plasma

sequence length :

461

purity :

>95% by SDS-PAGE analysis

form :

Liquid

concentration :

5.9 mg/ml

storage stability :

-20 degree C. Minimum shelf life is 12 months from delivery.

other info1 :

Specific Activity: <0.23% Avtivated Protein C activity

other info2 :

Buffer: 50% Glycerol. Extinction Coefficient: 1.45

products categories :

Protein C; Human Protein C

products description :

Human protein C is prepared from fresh frozen citrated human plasma using a combination of immunoaffinity chromatography and conventional techniques. Purity is determined by SDS-PAGE analysis and background activated protein C activity is measured using a chromogenic substrate based assay.

ncbi gi num :

4506115

ncbi acc num :

NP_000303.1

ncbi gb acc num :

NM_000312.3

uniprot acc num :

P04070

ncbi mol weight :

62,000

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Gamma-carboxylation Of Protein Precursors Pathway (106233); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Hemostasis Pathway (106028); Metabolism Of Proteins Pathway (106230)

ncbi summary :

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

uniprot summary :

PROC: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family. Protein type: EC 3.4.21.69; Protease; Apoptosis. Chromosomal Location of Human Ortholog: 2q13-q14. Cellular Component: endoplasmic reticulum lumen; Golgi lumen; extracellular region. Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding. Biological Process: cellular protein metabolic process; negative regulation of blood coagulation; proteolysis; blood coagulation; post-translational protein modification; leukocyte migration; peptidyl-glutamic acid carboxylation; negative regulation of apoptosis. Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Recessive; Thrombophilia Due To Protein C Deficiency, Autosomal Dominant

size1 :

0.1 mg

price1 :

435 USD

size2 :

1 mg

price2 :

1965

more info or order :

MyBioSource product webpage