protein

Human Antithrombin III

MBS135800

1 mg

220 USD

Protein

Human Antithrombin III

Antithrombin III

antithrombin-III; Antithrombin-III; antithrombin-III; serpin C1; antithrombin III; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; Serpin C1

SERPINC1

SERPINC1; SERPINC1; AT3; AT3D; ATIII; THPH7; AT3; ATIII

ANT3_HUMAN

Human plasma

464

>95% by SDS-PAGE analysis

Frozen liquid

Concentration: 1.04 mg/ml

Store at -70 degree C. Shelf Life: 3 years from delivery. Shipping: Ships with dry ice.

Aliquot: 1 x 1.0mg. Volume: 0.962ml

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 7.4. Extinction Coefficient: 0.65

Antithrombin III; Human Antithrombin III

Prepared from fresh human plasma using several chromatographic steps.

4502261

NP_000479.1

NM_000488.3

P01008

58,200

Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Glypican 1 Network Pathway (138010); Hemostasis Pathway (106028)

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 1q25.1. Cellular Component: extracellular space; extracellular region; plasma membrane. Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding. Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient. Disease: Antithrombin Iii Deficiency

1 mg

220 USD

10 mg

1250