Human alpha 2 antiplasmin | MyBioSource MBS135773 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human alpha 2 antiplasmin

catalog :

MBS135773

quantity :

1 mg

price :

575 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS135773

products type :

Protein

products full name :

Human alpha 2 antiplasmin

products short name :

[alpha 2 antiplasmin]

other names :

[alpha-2-antiplasmin isoform a; Alpha-2-antiplasmin; alpha-2-antiplasmin; serpin F2; alpha-2-AP; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2]

products gene name :

[SERPINF2]

other gene names :

[SERPINF2; SERPINF2; AAP; API; PLI; A2AP; ALPHA-2-PI; AAP; PLI; Alpha-2-AP; Alpha-2-PI]

uniprot entry name :

A2AP_HUMAN

host :

Human plasma

sequence length :

491

purity :

>95% by SDS-PAGE analysis

form :

Lyophilized Powder

concentration :

Lyophilized

storage stability :

Store at -70 degree C. Shelf Life: 3 years from delivery. Shipping: Ships with Dry Ice.

image1 heading :

Testing Data

other info1 :

Specific Activity: 7.94 U/mg (One unit will completely inhibit the activity of plasmin to hydrolyze one micromole of Tosyl-Gly-Pro-Lys-p-nitroanilide in one minute at 25 degree C and pH 8.0). Source: Human Plasma

other info2 :

Buffer: 0.02M Bis-Tris; 0.2M NaCl; pH 6.4. Extinction Coefficient: 0.73

products categories :

Plasminogen/Plasmin/Antiplasmin; Human Antiplasmin

products description :

Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma at about 70 ug per ml. Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.

ncbi gi num :

115583663

ncbi acc num :

NP_000925.2

ncbi gb acc num :

NM_000934.3

uniprot acc num :

P08697

ncbi mol weight :

70,000

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (106061); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

uniprot summary :

SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 17p13. Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity. Biological Process: platelet activation; collagen fibril organization; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; response to organic substance; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; renin-angiotensin regulation of blood vessel size; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; blood coagulation. Disease: Alpha-2-plasmin Inhibitor Deficiency

size1 :

1 mg

price1 :

575 USD

size2 :

10 mg

price2 :

4500

more info or order :

MyBioSource product webpage