catalog number :
MBS135764
products full name :
Soluble Mouse uPAR, His-tagged
products short name :
[Soluble Mouse uPAR]
other names :
[urokinase plasminogen activator surface receptor; Urokinase plasminogen activator surface receptor; urokinase plasminogen activator surface receptor; urokinase plasminogen activator receptor; urokinase-type plasminogen activator receptor; plasminogen activator, urokinase receptor]
products gene name :
[PLAUR]
other gene names :
[Plaur; Plaur; Cd87; uPAR; u-PAR; U-PAR; uPAR]
uniprot entry name :
UPAR_MOUSE
host :
Insect cell culture
purity :
>95% by SDS-PAGE analysis
form :
Frozen liquid, 0.1M Tris-HCl; 0.15M NaCl; pH 7.0
concentration :
0.6 mg/mL
storage stability :
Store at -70°C. Shelf Life: 3 years from delivery. Shipping: Dry Ice
other info1 :
Tag: His-tagged. Extinction Coefficient: 0.766
products categories :
Urokinase (uPA); Mouse uPA Receptor
products description :
Mouse Urokinase Receptor, Soluble form. Recombinantly produced in insect cells. Contains a 6X-Histidine tag at N terminus for purification. Demonstrates preferential binding to mouse uPA over human uPA coated on an ELISA plate.
ncbi acc num :
NP_035243.1
ncbi gb acc num :
NM_011113.3
ncbi pathways :
Attachment Of GPI Anchor To UPAR Pathway (765613); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (765587); Hemostasis Pathway (765555); Metabolism Of Proteins Pathway (765593); PodNet: Protein-protein Interactions In The Podocyte Pathway (755428); Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway (765610); Post-translational Protein Modification Pathway (765602)
uniprot summary :
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Receptor, misc.; Motility/polarity/chemotaxis. Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; extracellular region. Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor binding. Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis