Alpha-2-Macroglobulin, Human Plasma | MyBioSource MBS135740 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alpha-2-Macroglobulin, Human Plasma

catalog :

MBS135740

quantity :

5 mg

price :

490 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS135740

products type :

Protein

products full name :

Alpha-2-Macroglobulin, Human Plasma

products short name :

[Alpha-2-Macroglobulin, Human Plasma]

other names :

[alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5]

products gene name :

[A2M]

other gene names :

[A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M]

uniprot entry name :

A2MG_HUMAN

host :

Human plasma

sequence length :

1474

purity :

>95% by SDS-PAGE analysis

form :

Lyophilized powder

concentration :

lyophilized

storage stability :

Store at -70 degree C. Shelf Life: 3 years from delivery

image1 heading :

Testing Data

other info2 :

Buffer: 0.03M Sodium Phosphate; 0.1M Glycine; pH 7.0. Extinction Coefficient: 0.81

products categories :

Plasma Proteins; Human Plasma Proteins

products description :

A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport functions for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. Prepared from plasma shown to be non reactive for HbsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95% pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.

ncbi gi num :

66932947

ncbi acc num :

NP_000005.2

ncbi gb acc num :

NM_000014.4

uniprot acc num :

P01023

ncbi mol weight :

725,000

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway (106059); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156)

ncbi summary :

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

uniprot summary :

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-8 binding; interleukin-1 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; extracellular matrix organization and biogenesis; regulation of small GTPase mediated signal transduction; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

size1 :

5 mg

price1 :

490 USD

size2 :

10 mg

price2 :

780

more info or order :

MyBioSource product webpage