Human Prothrombin | MyBioSource MBS135728 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Prothrombin

catalog :

MBS135728

quantity :

9 mg

price :

325 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135728

products type :

Protein

products full name :

Human Prothrombin

products short name :

Prothrombin

other names :

prothrombin preproprotein; Prothrombin; prothrombin; serine protease; prothrombin B-chain; prepro-coagulation factor II; coagulation factor II (thrombin); Coagulation factor II

products gene name :

other gene names :

F2; F2; PT; THPH1; RPRGL2

uniprot entry name :

THRB_HUMAN

host :

Human plasma

sequence length :

622

purity :

>95% by SDS-PAGE analysis

form :

Frozen liquid

concentration :

8.71 mg/ml

storage stability :

Store at -70 degree C. Shelf Life: 3 years from delivery

other info1 :

Volume: 1.033ml. Aliquot: 1 x 9.0 mg

other info2 :

Buffer: 0.02M Tris-HCl; 0.1M NaCl; pH 7.4. Extinction Coefficient: 1.38

products categories :

Thrombin/Prothrombin; Human Prothrombin

products description :

Human prothrombin is prepared from fresh frozen human plasma. Human Prothrombin is a glycoprotein of molecular weight 72,000, and consists of a single polypeptide chain. Activation of Prothrombin by Factor Va, Xa and phospholipids yields the serine protea

ncbi gi num :

4503635

ncbi acc num :

NP_000497.1

ncbi gb acc num :

NM_000506.3

uniprot acc num :

P00734

ncbi mol weight :

72,000

ncbi pathways :

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Cell Surface Interactions At The Vascular Wall Pathway (106062); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057)

ncbi summary :

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]

uniprot summary :

prothrombin: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Defects in F2 are the cause of factor II deficiency (FA2D). It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1). It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2). A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.21.5; Apoptosis. Chromosomal Location of Human Ortholog: 11p11. Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane. Molecular Function: protein binding; growth factor activity; serine-type endopeptidase activity; calcium ion binding; receptor binding. Biological Process: positive regulation of blood coagulation; multicellular organismal development; positive regulation of collagen biosynthetic process; proteolysis; regulation of cell shape; negative regulation of fibrinolysis; cell surface receptor linked signal transduction; positive regulation of cell proliferation; response to wounding; acute-phase response; negative regulation of proteolysis; platelet activation; cytosolic calcium ion homeostasis; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; fibrinolysis; cellular protein metabolic process; regulation of gene expression; regulation of blood coagulation; negative regulation of astrocyte differentiation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of protein amino acid phosphorylation; blood coagulation; blood coagulation, intrinsic pathway; leukocyte migration. Disease: Thrombophilia Due To Thrombin Defect; Stroke, Ischemic; Prothrombin Deficiency, Congenital; Pregnancy Loss, Recurrent, Susceptibility To, 2

size1 :

9 mg

price1 :

325 USD

size2 :

90 mg

price2 :

2710

more info or order :

MyBioSource product webpage