catalog number :
MBS135715
products full name :
Mouse Fibronectin
products short name :
Fibronectin
other names :
fibronectin isoform a; Fibronectin; fibronectin; fibronectin 1
other gene names :
Fn1; Fn1; Fn; Fn-1; E330027I09; FN
uniprot entry name :
FINC_MOUSE
purity :
>95% by SDS-PAGE analysis
concentration :
1.0 mg/ml
storage stability :
Store at -70 degree C. Shelf Life: 3 years from delivery
other info2 :
Buffer: 0.1 M Tris-HCl; 0.15 M NaCl; pH 7.4. Extinction Coefficient: 1.28
products categories :
Fibronectin; Mouse Fibronectin
products description :
Prepared from fresh mouse plasma. Ideal reagent for tissue culture studies and protein-protein interactions. Thaw the fibronectin by placing the vial in a 37 C water bath and leaving it undisturbed until completely thawed. Do not disturb the vial at any time during the thawing process. If the vial is disturbed or removed prior to complete thawing, the fibronectin will form a gel and be unusable. Mix very gently with pipette after thawing. Vortexing, excessive agitation, repeated freezing and thawing of fibronectin are not recommended.
ncbi acc num :
NP_034363.1
ncbi gb acc num :
NM_010233.2
ncbi mol weight :
220,000
ncbi pathways :
Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Bacterial Invasion Of Epithelial Cells Pathway (149817); Bacterial Invasion Of Epithelial Cells Pathway (148661); Cell Surface Interactions At The Vascular Wall Pathway (765588); ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (765829); Fibronectin Matrix Formation Pathway (765835); Focal Adhesion Pathway (198353)
uniprot summary :
FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Secreted; Cell adhesion; Secreted, signal peptide. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; fibrinogen complex; apical plasma membrane; ER-Golgi intermediate compartment; extracellular region; basement membrane; basal lamina. Molecular Function: heparin binding; integrin binding; protein binding; protease activator activity; protease binding; mercury ion binding. Biological Process: integrin activation; extracellular matrix organization and biogenesis; wound healing; positive regulation of chemotaxis; cell-matrix adhesion; positive regulation of axon extension; glial cell migration; cell activation; regulation of cell shape; calcium-independent cell-matrix adhesion; acute-phase response; cell-substrate junction assembly; peptide cross-linking; angiogenesis; cell adhesion; positive regulation of cell migration; negative regulation of apoptosis