protein

Human GPIIbIIIa

MBS135714

1 mg

460 USD

Protein

Human GPIIbIIIa

GPIIbIIIa

integrin alpha-IIb preproprotein; Integrin alpha-IIb; integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb

ITGA2B

ITGA2B; ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; GP2B; ITGAB; GPIIb

ITA2B_HUMAN

Human plasma

1039

>95% by SDS-PAGE analysis

Liquid

1.82 mg/ml. Volume: 0.549 ml. Aliquot: 1 x 1.0 mg

Store at -20 degree C. Shelf Life: 12 months from delivery

Buffer: 0.02M Tris-HCl; 0.1M NaCl; 0.1% Triton X-100; 0.001M CaCl2; 0.05% NaN3; 50% glycerol; pH 7.4. Extinction Coefficient: 0.91. Preservative: SodiumAzide

Platelet Proteins; Human Platelet Glycoproteins

GPIIb and GPIIIa migrates on gels as follows: GPIIb 136,000 non-reduced and 125,000 reduced. GPIIIa is 97,000 non-reduced and 108,000 reduced. Protein concentration is determined via the Bradford method.

88758615

NP_000410.2

NM_000419.3

P08514

Mixed

Arf6 Signaling Events Pathway (138034); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479)

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: platelet alpha granule membrane; focal adhesion; cell surface; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding. Biological Process: integrin-mediated signaling pathway; platelet activation; axon guidance; extracellular matrix organization and biogenesis; platelet degranulation; positive regulation of leukocyte migration; cell-matrix adhesion; blood coagulation; cell adhesion. Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16

1 mg

460 USD

2 mg

725