Human coagulation Factor XIIIa | MyBioSource MBS135706 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human coagulation Factor XIIIa

catalog :

MBS135706

quantity :

0.25 mg

price :

580 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135706

products type :

Protein

products full name :

Human coagulation Factor XIIIa

products short name :

coagulation Factor XIIIa

other names :

coagulation factor XIII A chain; Coagulation factor XIII A chain; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII, A1 polypeptide; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain

products gene name :

F13

other gene names :

F13A1; F13A1; F13A; F13A; Coagulation factor XIIIa

uniprot entry name :

F13A_HUMAN

host :

Human plasma

sequence length :

732

purity :

>95% by SDS-PAGE analysis

form :

Liquid

concentration :

1.25 mg/ml (Volume: 0.2ml)

storage stability :

Store at -20 degree C. Shelf Life: 12 months from delivery

other info1 :

Specific Activity: 2000 Loewy u/mg (1 plasma equivalent unit (PEU) is equal to approximately 10^8 Loewy units)

other info2 :

Buffer: 0.05M Tris-HCl; 0.1M NaCl; 0.001M EDTA; 10 U/ml Aprotinin; 0.05mM DTT; 50% Glycerol; pH 7.5. Extinction Coefficient: 1.38

products categories :

Factor XIII; Human Factor XIIIa

products description :

Human Factor XIIIa is activated from Factor XIII by cleavage with human alpha thrombin. The thrombin is subsequently removed via chromatography. Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase

ncbi gi num :

119395709

ncbi acc num :

NP_000120.2

ncbi gb acc num :

NM_000129.3

uniprot acc num :

P00488

ncbi mol weight :

312,000

ncbi pathways :

Common Pathway (106060); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

uniprot summary :

F13A1: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD). FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Belongs to the transglutaminase superfamily. Transglutaminase family. Protein type: Transferase; EC 2.3.2.13. Chromosomal Location of Human Ortholog: 6p25.3-p24.3. Cellular Component: extracellular region. Molecular Function: protein-glutamine gamma-glutamyltransferase activity; metal ion binding. Biological Process: platelet activation; platelet degranulation; peptide cross-linking; blood coagulation. Disease: Thrombophilia Due To Thrombin Defect; Myocardial Infarction, Susceptibility To; Factor Xiii, A Subunit, Deficiency Of

size1 :

0.25 mg

price1 :

580 USD

size2 :

1 mg

price2 :

1355

more info or order :

MyBioSource product webpage