protein

Alpha-2-HS-Glycoprotein, Human Plasma

MBS135677

1 mg

345 USD

Protein

Alpha-2-HS-Glycoprotein, Human Plasma

Alpha-2-HS-Glycoprotein, Human Plasma

alpha-2-HS-glycoprotein preproprotein; Alpha-2-HS-glycoprotein; alpha-2-HS-glycoprotein; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein; alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A

AHSG

AHSG; AHSG; AHS; A2HS; HSGA; FETUA; FETUA

FETUA_HUMAN

Human plasma

367

>95% by SDS-PAGE analysis

Lyophilized powder

Lyophilized . Volume: 0.296 ml before lyophilization

Store at -70 degree C. Shelf Life: 3 years from delivery

Aliquot: 5 x 1.0 mg

Buffer: 0.02M Tris-HCl; 0.2M NaCl; pH 8.0. Extinction Coefficient: 0.54

Plasma Proteins; Human Plasma Proteins

Found in human serum at 60 mg per 100 ml. This protein is a negative acute-phase reactant. Clinically, concentrations are reduced in cancer patients. AHSG levels are positively correlated with gestational diabetes and negatively correlated with neonatal skeletal development. Studies show AHSG to be present at high concentrations in the peritoneal fluids of patients with endometriosis. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests, > 95 percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unsused portion.

156523970

NP_001613.2

NM_001622.2

P02765

49,000

BMP Receptor Signaling Pathway (137948)

Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 3q27. Cellular Component: extracellular space; extracellular region. Molecular Function: kinase inhibitor activity; cysteine protease inhibitor activity. Biological Process: negative regulation of bone mineralization; pinocytosis; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; regulation of bone mineralization; skeletal development

1 mg

345 USD

5 mg

635