protein

Human Platelet Factor 4

MBS135676

0.1 mg

415 USD

Protein

Human Platelet Factor 4

[Platelet Factor 4]

[platelet factor 4; Platelet factor 4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; platelet factor 4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A]

[PF4]

[PF4; PF4; PF-4; CXCL4; SCYB4; CXCL4; SCYB4; PF-4]

PLF4_HUMAN

101

>95% by SDS-PAGE analysis

Frozen liquid

3.3mg/ml

Recommended storage: Store at -70°C. Shipping conditions: Dry Ice. Shelf Life: 3 years from delivery

Testing Data

Source: Human Plasma. Specific Activity: 125 U/mg (1 unit will neutralize 1 I.U. of heparin in 1 ml of normal plasma)

Buffer: 0.025M HEPES; 2.0M NaCl; pH 7.4. Extinction Coefficient: 0.26

Platelet Proteins; Human Platelet Factor 4

Human PF-4 is prepared from the supernatant of thrombin-activated platelets by heparin-agarose affinity chromatography. Purity is assessed by SDS-PAGE analysis and heparin-neutralizing activity is verified by clotting assay.

4505733

NP_002610.1

NM_002619.3

P02776

29,000

CXCR3-mediated Signaling Events Pathway (138011); Cell Surface Interactions At The Vascular Wall Pathway (106062); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway (106060); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057)

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]

PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Apoptosis; Secreted. Chromosomal Location of Human Ortholog: 4q12-q21. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity. Biological Process: negative regulation of cytolysis; platelet activation; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; platelet degranulation; negative regulation of MHC class II biosynthetic process; immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; inflammatory response; positive regulation of macrophage differentiation

0.1 mg

415 USD

0.5 mg

1060