protein

Human coagulation Factor XIa

MBS135660

0.1 mg

435 USD

Protein

Human coagulation Factor XIa

[coagulation Factor XIa]

[coagulation factor XI; Coagulation factor XI; coagulation factor XI; PTA; plasma thromboplastin antecedent; coagulation factor XI; Plasma thromboplastin antecedent]

[F11]

[F11; F11; FXI; FXI; PTA]

FA11_HUMAN

Human plasma

625

>95% by SDS-PAGE analysis

Frozen liquid

1.24 mg/ml

Store at -70 degree C. Shelf Life: 3 years from delivery. Shipping: Dry Ice

Specific Activity: 227.7 IU/mg

Buffer: 4 mM Sodium Acetate; 0.15 M NaCl; pH 5.3. Extinction Coefficient: 1.34

Factor XI; Human Factor XIa

Human Factor XIa is prepared from Human Factor XI using Human Factor Xlla. Factor Xlla is removed using a corn trypsin inhibitor column. Factor XI is activated to Factor XIa by Factor Xlla and High Molecular Weight Kininogen in the contact pathway of the coagulation cascade. FXI undergoes proteolytic cleavage in which the 80,000 chain reportedly is cleaved to a heavy and light chain with molecular weights of about 48,000 and 33,000. Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces. Complete activation and >95percent purity is observed by SDS-PAGE. Prepared from plasma found negative by FDA accepted methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

4503627

NP_000119.1

NM_000128.3

P03951

160,000 Non-reduced

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Intrinsic Pathway (106059)

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.21.27. Chromosomal Location of Human Ortholog: 4q35. Cellular Component: extracellular space; membrane; extracellular region; plasma membrane. Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity. Biological Process: positive regulation of fibrinolysis; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation. Disease: Factor Xi Deficiency

0.1 mg

435 USD

1 mg

2185