catalog number :
MBS135657
products full name :
Low Endotoxin Human RAP
products short name :
Low Endotoxin Human RAP
other names :
alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); low density lipoprotein receptor-related protein associated protein 1; Low density lipoprotein receptor-related protein-associated protein 1
products gene name :
LRPAP1
other gene names :
LRPAP1; LRPAP1; RAP; MRAP; A2RAP; HBP44; A2MRAP; A2MRAP; Alpha-2-MRAP; RAP
uniprot entry name :
AMRP_HUMAN
purity :
>95% by SDS-PAGE analysis
concentration :
3.0mg/ml; 0.75 EU/mg (Volume: 0.167ml)
storage stability :
Store at -70 degree C. Shelf Life: 3 years from delivery
other info2 :
Buffer: 0.0067M Phosphate; 0.15M NaCl; pH 7.4. Extinction Coefficient: 0.93
products categories :
Receptor Associated Protein (RAP); Human RAP
products description :
This preparation of Receptor Associated Protein is purified to lower levels of endotoxin. Low endotoxin RAP is suitable for experiments involving signaling events and phosphorylation studies, which may be triggered by endotoxin.
ncbi acc num :
NP_002328.1
ncbi gb acc num :
NM_002337.3
ncbi pathways :
Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Reelin Signaling Pathway (137980); Signaling Events Mediated By The Hedgehog Family Pathway (137950)
ncbi summary :
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
uniprot summary :
LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. Protein type: Receptor, misc. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: cell surface; endoplasmic reticulum; plasma membrane; integral to membrane; extracellular region; vesicle. Molecular Function: heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity. Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding. Disease: Myopia 23, Autosomal Recessive