product summary
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company name :
MyBioSource
product type :
protein
product name :
Bovine plasminogen
catalog :
MBS135654
quantity :
1 mg
price :
235 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS135654
products type :
Protein
products full name :
Bovine plasminogen
products short name :
Bovine plasminogen
other names :
plasminogen; Plasminogen; plasminogen; lipoprotein, Lp(a)
products gene name :
PLG
other gene names :
PLG; PLG; LPA
uniprot entry name :
PLMN_BOVIN
host :
Bovine plasma
sequence length :
812
purity :
>95% by SDS-PAGE analysis
form :
Frozen liquid
concentration :
4.5 mg/ml
storage stability :
Store at -70 degree C. Shelf Life: 3 years from delivery
other info1 :
Volume: 0.222ml. Aliquot: 1 x 1.0mg
other info2 :
Buffer: 0.1M HEPES; 0.1M NaCl; pH 7.4. Extinction Coefficient: 1.69
products categories :
Plasminogen/Plasmin/Antiplasmin; Bovine Plasminogen and Plasmin
products description :
Prepared from fresh bovine plasma by immobilized lysine chromatography.
ncbi gi num :
27806815
ncbi acc num :
NP_776376.1
ncbi gb acc num :
NM_173951.2
uniprot acc num :
P06868
ncbi mol weight :
92,000
ncbi pathways :
Complement And Coagulation Cascades Pathway (84312); Complement And Coagulation Cascades Pathway (484); Influenza A Pathway (217172); Influenza A Pathway (217150); Neuroactive Ligand-receptor Interaction Pathway (84292); Neuroactive Ligand-receptor Interaction Pathway (462); Staphylococcus Aureus Infection Pathway (172831); Staphylococcus Aureus Infection Pathway (171867)
uniprot summary :
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells . By similarity. Catalytic activity: Preferential cleavage: Lys- -Xaa > Arg- -Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. Enzyme regulation: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Cannot be activated with streptokinase. Subunit structure: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation . By similarity. Subcellular location: Secreted . By similarity. Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface . By similarity. Domain: Kringle domains mediate interaction with CSPG4 . By similarity. Post-translational modification: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues (microheterogeneity).In the presence of the inhibitor, the activation involves only cleavage after Arg-583, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide . By similarity. Miscellaneous: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot. Sequence similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.Contains 5 kringle domains.Contains 1 PAN domain.Contains 1 peptidase S1 domain.
size1 :
1 mg
price1 :
235 USD
size2 :
10 mg
price2 :
1405
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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