catalog number :
MBS135646
products full name :
Prekallikrein, Human Plasma
products short name :
Prekallikrein, Human Plasma
other names :
kallikrein-1 preproprotein; Kallikrein-1; kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein; kallikrein 1; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
products gene name :
KLK1
other gene names :
KLK1; KLK1; hK1; KLKR; Klk6
uniprot entry name :
KLK1_HUMAN
purity :
>95% by SDS-PAGE analysis
concentration :
0.833 mg/ml. Aliquot: 1 x 1.0mg. Volume: 1.2 ml
storage stability :
Store at -70 degree C. Shelf Life: 3 years from delivery
other info2 :
Buffer: 0.004M Sodium Acetate; 0.15M NaCl; pH 5.3. Extinction Coefficient: 1.17
products categories :
Kallikrein/Prekallikrein; Human Prekallikrein
products description :
Zymogen precursor of the plasma serine protease kallikrein. >95percent pure by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.
ncbi acc num :
NP_002248.1
ncbi gb acc num :
NM_002257.2
ncbi pathways :
Blood Clotting Cascade Pathway (198840); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Metabolism Of Proteins Pathway (106230); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)
ncbi summary :
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
uniprot summary :
KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.35; Protease. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: nucleus. Molecular Function: serine-type endopeptidase activity. Biological Process: proteolysis. Disease: Kallikrein, Decreased Urinary Activity Of