Haptoglobin, Human Plasma | MyBioSource MBS135642 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Haptoglobin, Human Plasma

catalog :

MBS135642

quantity :

5 mg

price :

380 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135642

products type :

Protein

products full name :

Haptoglobin, Human Plasma

products short name :

Haptoglobin, Human Plasma

other names :

haptoglobin isoform 2 preproprotein; Haptoglobin; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; haptoglobin; Zonulin

products gene name :

other gene names :

HP; HP; BP; HPA1S; HP2ALPHA2

uniprot entry name :

HPT_HUMAN

host :

Human plasma

sequence length :

347

purity :

>95% by SDS-PAGE analysis

form :

Lyophilized powder

concentration :

Lyophilized

storage stability :

Store at -70 degree C. Shelf Life: 3 years from delivery. Shipping: Ships with cold packs

other info2 :

Buffer: Salt free. Extinction Coefficient: 1.2

products categories :

Plasma Proteins; Human Plasma Proteins

products description :

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes. Hp 1-1 is the most common, and the most effective in binding free hemoglobin. Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HbsAG, anti-HCY, anti-HBc, and negative for anti-HIY I & 2 by FDA approved tests >95 percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion. Molecular Weights by phenotype - Hp 1- 86,000: Hp 2-1: 200.000: Hp 2-2: 400,000.

ncbi gi num :

186910296

ncbi acc num :

NP_001119574.1

ncbi gb acc num :

NM_001126102.1

uniprot acc num :

P00738

ncbi mol weight :

Multiple

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response. Disease: Anhaptoglobinemia

size1 :

5 mg

price1 :

380 USD

size2 :

10 mg

price2 :

550

more info or order :

MyBioSource product webpage