protein

Human Factor X

MBS135631

0.5 mg

480 USD

Protein

Human Factor X

[Factor X]

[coagulation factor X preproprotein; Coagulation factor X; coagulation factor X; factor Xa; prothrombinase; Stuart-Prower factor; coagulation factor X; Stuart factor; Stuart-Prower factor]

[F10]

[F10; F10; FX; FXA]

FA10_HUMAN

488

>95% by SDS-PAGE analysis

Liquid

7.7 mg/mL

Storage: -20°C . Shipping conditions: Cold pack. Shelf life: 12 months from delivery

Source: Human plasma. Aliquot: 5 x 0.1 mg. Volume: 0.0735 ml. Specific Activity: 121 U/mg. Volume: 0.013 mL. Specific Activity: 121 U/mg

Buffer: 50% Glycerol. Extinction Coefficient: 1.16

Factor X; Human Factor X

Human factor X is isolated from fresh frozen human plasma by a combination of conventional techniques and immunoaffinity chromatography. In addition to the standard human factor X preparation, Gla-domainless human factor X is also available. Purity is determined by SDS-PAGE analysis and activity is measured in a a factor X clotting assay,

4503625

NP_000495.1

NM_000504.3

P00742

58,900

Blood Clotting Cascade Pathway (198840); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (106058); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Gamma-carboxylation Of Protein Precursors Pathway (106233); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Hemostasis Pathway (106028)

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]

F10: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Defects in F10 are the cause of factor X deficiency (FA10D). A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. Belongs to the peptidase S1 family. Protein type: Lipid-binding; EC 3.4.21.6; Secreted; Motility/polarity/chemotaxis; Protease; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region. Molecular Function: protein binding; serine-type endopeptidase activity; phospholipid binding; calcium ion binding. Biological Process: positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; post-translational protein modification; blood coagulation; proteolysis; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation; positive regulation of cell migration. Disease: Factor X Deficiency

0.5 mg

480 USD

5 mg

2500