catalog number :
MBS135564
products type :
Immunoglobulin
products full name :
IgA, Human Plasma
products short name :
[IgA, Human Plasma]
other names :
[Ig alpha-1 chain C region; Ig alpha-1 chain C region; immunoglobulin heavy constant alpha 1]
products gene name :
[IGHA1]
other gene names :
[IGHA1; IGHA1; IgA1]
uniprot entry name :
IGHA1_HUMAN
purity :
>95% by SDS-PAGE analysis
concentration :
3.8 mg/ml
storage stability :
Store at -70°C. Shelf Life: 3 years from delivery. Shipping: Dry Ice.
other info2 :
Buffer: 0.1M Tris-HCl; 0.1M NaCl; pH 8.0. Extinction Coefficient: 1.32
products categories :
Human Immunoglobulins; Human Immunoglobulins
products description :
Purified from single donor human serwn by affinity chromatography (Doner ID 57460). IgA is the most abundant immunoglobulin in body fluids and the second most abundant immunoglobulin in plasma, found at a concentration of 0.4 to 2.2 mglml. It plays a very important role in the first specific defense against natural infection. Secretory IgA differs from serum IgA in that it contains two additional peptides: the secretory component and the J chain. Prepared from plasma shown to be non reactive for HbsAG, anti-HCY, anti-HBc, and negative for anti-HIV I & 2 by FDA approved tests. >95percent pure by SDS-PAGE.
ncbi mol weight :
160,000
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Inflammatory Response Pathway (198766); Regulation Of Nuclear SMAD2/3 Signaling Pathway (137963); Scavenging Of Heme From Plasma Pathway (771600)
uniprot summary :
IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. Protein type: Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: antigen binding. Biological Process: receptor-mediated endocytosis; retinal homeostasis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage