Anti-Catalase, Human Erythrocyte, Rabbit IgG Fraction | MyBioSource MBS135477 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Catalase, Human Erythrocyte, Rabbit IgG Fraction

catalog :

MBS135477

quantity :

1 mL

price :

425 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135477

products type :

Antibody

products full name :

Anti-Catalase, Human Erythrocyte, Rabbit IgG Fraction

products short name :

[Catalase, Human Erythrocyte, Rabbit IgG Fraction]

other names :

[catalase; Catalase; catalase; catalase]

products gene name :

[CAT]

other gene names :

[CAT; CAT]

uniprot entry name :

CATA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

527

purity :

IgG fraction

form :

Liquid

concentration :

1.96 mg/ml

storage stability :

Recommended Storage: 4°C . Shipping conditions: Cold pack. Minimum Shelf Life: 5 years from delivery.

tested application :

ELISA (EIA), Western Blot (WB), Ie

other info1 :

Source: Rabbit Serum. Antigen: Full length native protein (purified) (Human). Target : Recognizes Catalase. Target Molecular Weight: 230,000. Aliquot: 1 x 1.0 ml

other info2 :

Buffer: PBS; 0.1% Azide. Extinction Coefficient: 1.36. Preservative: Sodium Azide

products categories :

Elastase, Proteases; Polyclonal Antibodies to Human Catalase

products description :

Polyclonal antibody (host rabbit). IgG fraction purified by immobilized Protein A. Reacts to human erythrocyte catalase.

ncbi gi num :

4557014

ncbi acc num :

NP_001743.1

ncbi gb acc num :

NM_001752.3

uniprot acc num :

P04040

ncbi mol weight :

160,000

ncbi pathways :

Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); DNA Damage Response (only ATM Dependent) Pathway (198827); Folate Metabolism Pathway (198833); FoxO Family Signaling Pathway (138036); Glyoxylate And Dicarboxylate Metabolism Pathway (83002); Glyoxylate And Dicarboxylate Metabolism Pathway (383); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Oxidative Stress Pathway (198916)

ncbi summary :

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

uniprot summary :

Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Protein type: Hydrolase; Endoplasmic reticulum; Oxidoreductase; Apoptosis; Energy Metabolism - methane; Mitochondrial; EC 1.11.1.6; Amino Acid Metabolism - tryptophan. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: Golgi apparatus; peroxisomal membrane; peroxisomal matrix; focal adhesion; membrane; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane; mitochondrial intermembrane space; peroxisome; cytosol. Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; catalase activity; metal ion binding; heme binding; NADP binding; aminoacylase activity; receptor binding. Biological Process: cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; purine base metabolic process; activation of NF-kappaB transcription factor; protein homotetramerization; positive regulation of phosphoinositide 3-kinase cascade; osteoblast differentiation; response to vitamin E; response to reactive oxygen species; triacylglycerol metabolic process; response to hyperoxia; UV protection; inhibition of NF-kappaB transcription factor; ureteric bud development; hydrogen peroxide catabolic process; positive regulation of cell division; aerobic respiration; response to hypoxia; purine nucleotide catabolic process; protein tetramerization; negative regulation of apoptosis; aging. Disease: Acatalasemia

size1 :

1 mL

price1 :

425 USD

size2 :

10 mL

price2 :

2915

more info or order :

MyBioSource product webpage