Sheep anti human factor XII IgG fraction, biotin labeled | MyBioSource MBS135473 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Sheep anti human factor XII IgG fraction, biotin labeled

catalog :

MBS135473

quantity :

1 mg

price :

345 USD

clonality :

polyclonal

host :

sheep

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135473

products type :

Antibody

products full name :

Sheep anti human factor XII IgG fraction, biotin labeled

products short name :

[factor XII IgG fraction, biotin labeled]

other names :

[coagulation factor XII; Coagulation factor XII; coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; coagulation factor XII (Hageman factor); Hageman factor]

products gene name :

[F12]

other gene names :

[F12; F12; HAF; HAE3; HAEX; HAF]

uniprot entry name :

FA12_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

sheep

reactivity :

Human

sequence length :

615

purity :

IgG fraction

form :

Frozen liquid

concentration :

3.5mg/ml

storage stability :

Store at -70 degree C. Shelf Life: 5 years from delivery. Shipping: Dry ice

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Full length native protein (purified) (Human). Target Information: Recognises Factor XII. Target Molecular Weight: 80,000. Aliquot: 1 x 1.0mg; 3.28 moles of biotin per mole antibody. Volume: 0.286ml

other info2 :

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36

products categories :

Factor XII; Polyclonal Antibodies to Human Factor XII

products description :

Biotin labeled polyclonal antibody (host sheep) to human factor XII. IgG fraction purified by immobilized Protein G.

ncbi gi num :

145275213

ncbi acc num :

NP_000496.2

ncbi gb acc num :

NM_000505.3

uniprot acc num :

P00748

ncbi mol weight :

160,000

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Intrinsic Pathway (106059)

ncbi summary :

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

uniprot summary :

F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family. Protein type: Chaperone; EC 3.4.21.38; Secreted, signal peptide; Secreted; Protease. Chromosomal Location of Human Ortholog: 5q35.3. Cellular Component: extracellular space; extracellular region; plasma membrane. Molecular Function: protein binding; serine-type endopeptidase activity; misfolded protein binding. Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; plasma kallikrein-kinin cascade; innate immune response; positive regulation of fibrinolysis; protein processing; zymogen activation; blood coagulation; blood coagulation, intrinsic pathway; Factor XII activation. Disease: Angioedema, Hereditary, Type Iii; Factor Xii Deficiency

size1 :

1 mg

price1 :

345 USD

size2 :

10 mg

price2 :

2210

more info or order :

MyBioSource product webpage