antibody

Biotin Labeled Anti mouse factor IX

MBS135307

1 mg

425 USD

polyclonal

sheep

biotin

western blot, ELISA, enzyme immunoassay

Antibody

Biotin Labeled Anti mouse factor IX

[Biotin Labeled Anti mouse factor IX]

[coagulation factor IX; Coagulation factor IX; coagulation factor IX; christmas factor; coagulation factor IX; Christmas factor]

[F9]

[F9; F9; Cf9; Cf-9; AW111646; Cf9]

FA9_MOUSE

Polyclonal

IgG

sheep

Mouse

471

IgG fraction

Frozen liquid

3.76mg/ml; 9.78 mole biotin/mole IgG

Store at -70 degree C. Shelf Life: 5 years from delivery. Shipping: Dry Ice

ELISA (EIA), Western Blot (WB)

Volume: 0.266ml. Immunogen: Full length native protein (purified) (Mouse). Target Information: Recognises Factor IX. Target Molecular Weight: 56000

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36

Factor IX; Polyclonal Antibodies to Mouse Factor IX

Biotin labeled polyclonal antibody (host sheep) to mouse factor IX. IgG fraction purified by immobilized Protein G.

73661202

NP_032005.1

NM_007979.1

P16294

160,000

Blood Clotting Cascade Pathway (198388); Complement And Coagulation Cascades Pathway (198335); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (765584); Formation Of Fibrin Clot (Clotting Cascade) Pathway (765583); Gamma-carboxylation Of Protein Precursors Pathway (765605); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (765604); Hemostasis Pathway (765555); Intrinsic Pathway (765585)

This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with factor VIII, membrane phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.21.22. Cellular Component: extracellular region. Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; catalytic activity. Biological Process: hemostasis; blood coagulation; proteolysis

1 mg

425 USD

10 mg

2785