Rabbit anti mouse fibrinogen IgG fraction | MyBioSource MBS135234 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti mouse fibrinogen IgG fraction

catalog :

MBS135234

quantity :

1 mg

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135234

products type :

Antibody

products full name :

Rabbit anti mouse fibrinogen IgG fraction

products short name :

[fibrinogen IgG fraction]

other names :

[fibrinogen, alpha polypeptide isoform 2; Fibrinogen, alpha polypeptide; fibrinogen, alpha polypeptide; fibrinogen, A alpha polypeptide; fibrinogen alpha chain]

products gene name :

[FGA]

other gene names :

[Fga; Fga; Fib; ENSMUSG00000059807]

uniprot entry name :

Q99K47_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

rabbit

reactivity :

Mouse, rat

sequence length :

557

purity :

IgG fraction

form :

Frozen liquid

concentration :

17 mg/ml. Aliquot: 1x 1.0mg. Volume: 0.06ml

storage stability :

Store at -70 degree C. Shelf Life: 5 years from delivery

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin

other info1 :

Immunogen: Full length native protein (purified) (Mouse). Target Information: Recognises Fibrinogen. Target Molecular Weight: 340000

other info2 :

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36

products categories :

Fibrinogen; Polyclonal Antibodies to Mouse Fibrinogen

products description :

Polyclonal antibody (host rabbit). IgG fraction purified by immobilized Protein A. Cross reacts with rat fibrinogen.

ncbi gi num :

33563252

ncbi acc num :

NP_034326.1

ncbi gb acc num :

NM_010196.3

uniprot acc num :

Q99K47

ncbi mol weight :

160,000

ncbi pathways :

Amyloids Pathway (765096); Blood Clotting Cascade Pathway (198388); Common Pathway (765586); Complement And Coagulation Cascades Pathway (83270); Complement And Coagulation Cascades Pathway (484); Disease Pathway (765074); Formation Of Fibrin Clot (Clotting Cascade) Pathway (765583); GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway (765575); Hemostasis Pathway (765555); Integrin AlphaIIb Beta3 Signaling Pathway (765574)

ncbi summary :

This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

uniprot summary :

FGA: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGA are a cause of congenital afibrinogenemia (CAFBN). This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha- dysfibrinogenemias. Defects in FGA are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; cell surface; rough endoplasmic reticulum; cytoplasm; fibrinogen complex; extracellular region; cell cortex; vesicle; external side of plasma membrane. Molecular Function: protein binding, bridging; cell adhesion molecule binding; structural molecule activity; receptor binding. Biological Process: protein polymerization; platelet activation; positive regulation of heterotypic cell-cell adhesion; cellular protein complex assembly; positive regulation of protein secretion; immune system process; hemostasis; cell-matrix adhesion; positive regulation of vasoconstriction; innate immune response; response to calcium ion; signal transduction; blood coagulation; positive regulation of exocytosis

size1 :

1 mg

price1 :

375 USD

size2 :

10 mg

price2 :

2410

more info or order :

MyBioSource product webpage