antibody

Sheep anti human cTnT IgG fraction, biotin labeled

MBS135202

1 mg

345 USD

polyclonal

sheep

biotin

western blot, ELISA, enzyme immunoassay

Antibody

Sheep anti human cTnT IgG fraction, biotin labeled

[cTnT IgG fraction, biotin labeled]

[troponin T, cardiac muscle isoform 1; Troponin T, cardiac muscle; troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant); troponin T type 2 (cardiac); Cardiac muscle troponin T]

[TNNT2]

[TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; TnTc; cTnT]

TNNT2_HUMAN

Polyclonal

IgG

Sheep

Human

295

IgG fraction

Frozen liquid

2.2 mg/ml

Store at -70 degree C. Shelf Life: 5 years from delivery. Shipping: Ships with Dry ice.

ELISA (EIA), Western Blot (WB)

Source: Sheep serum. Antigen: Full length native protein (purified) (Human). Target: Recognises cTnT. Target Molecular Weight: 36,000

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36. Aliquot: 1 x 1.0 mg

Cardiac Troponin T (cTnT); Polyclonal Antibodies to Human Cardiac Troponin T

Biotin labeled polyclonal antibody (host sheep) to human Cardiac Troponin T (cTnT). IgG fraction purified by immobilized Protein G.

48255877

NP_000355.2

NM_000364.3

P45379

160,000

Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament. Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding. Biological Process: metabolic process; atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding. Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

1 mg

345 USD

10 mg

2210