Sheep anti-Human Tissue Factor | MyBioSource MBS135165 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Sheep anti-Human Tissue Factor

catalog :

MBS135165

quantity :

1 mg

price :

285 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135165

products type :

Antibody

products full name :

Sheep anti-Human Tissue Factor

products short name :

[Tissue Factor]

other names :

[tissue factor isoform 2; Tissue factor; tissue factor; coagulation factor III (thromboplastin, tissue factor); Coagulation factor III; Thromboplastin]

products gene name :

[F3]

other gene names :

[F3; F3; TF; TFA; CD142; TF]

uniprot entry name :

TF_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Sheep

reactivity :

Human

sequence length :

238

purity :

IgG fraction

form :

Liquid

concentration :

13.0 mg/ml

storage stability :

Store at -20 degree C. Shelf Life: 12 months from delivery. Shipping: Cold pack

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Source: Sheep serum. Immunogen: Full length native protein (purified) (Human). Target Information: Recognises Tissue Factor. Target Molecular Weight: 46,000

other info2 :

Buffer: 50% Glycerol. Extinction Coefficient: 1.36

products categories :

Tissue Factor; Polyclonal Antibodies to Human Tissue Factor Pathway Inhibitor

products description :

Polyclonal antibody (host sheep). IgG fraction purified by immobilized Protein G.

ncbi gi num :

296010912

ncbi acc num :

NP_001171567.1

ncbi gb acc num :

NM_001178096.1

uniprot acc num :

P13726

ncbi mol weight :

160,000

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (106058); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028)

ncbi summary :

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

uniprot summary :

F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p22-p21. Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding. Biological Process: caspase activation; positive regulation of protein kinase B signaling cascade; activation of blood coagulation via clotting cascade; positive regulation of angiogenesis; activation of plasma proteins during acute inflammatory response; blood coagulation, extrinsic pathway; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration

size1 :

1 mg

price1 :

285 USD

size2 :

5 mg

price2 :

550

more info or order :

MyBioSource product webpage