catalog number :
MBS1351256
products type :
Recombinant Protein
products full name :
Recombinant Streptococcus pyogenes serotype M28 (strain MGAS6180) Streptopain
products short name :
Streptopain
products name syn :
Exotoxin type B; SPE B; Streptococcal cysteine proteinase; Streptococcus peptidase A; SPP
other names :
streptopain; Streptopain; Exotoxin type B; SPE B; Streptococcal cysteine proteinase; Streptococcus peptidase A; SPP
products gene name :
speB
other gene names :
speB; SPP
uniprot entry name :
SPEB_STRPM
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
146-398
sequence :
QPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFV
GQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNP
YFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAIS
ELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQS
VHQINRSDFSKQDWESQIDKELSQNQPVYYQGVGKVGGH
AFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGT
GGGAGGFNGYQSAVVGIKP
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Streptococcus pyogenes serotype M28 (strain MGAS6180)
products categories :
Microbiology
products description :
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing
products references :
A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin." Kapur V., Topouzis S., Majesky M.W., Li L.L., Hamrick M.R., Hamill R.J., Patti J.M., Musser J.M. Microb. Pathog. 15:327-346(1993)
ncbi acc num :
WP_011285235.1
ncbi gb acc num :
WP_011285235.1
ncbi mol weight :
43,190 Da
size5 :
0.05 mg (Baculovirus)