Anti Human VLDL receptor, clone 1H10 | MyBioSource MBS135058 product information

product summary

company name :

MyBioSource

product type :

other

product name :

Anti Human VLDL receptor, clone 1H10

catalog :

MBS135058

quantity :

1 mg

price :

565 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135058

products type :

Antibody

products full name :

Anti Human VLDL receptor, clone 1H10

products short name :

[VLDL receptor, clone 1H10]

other names :

[very low-density lipoprotein receptor isoform b; Very low-density lipoprotein receptor; very low-density lipoprotein receptor; VLDL-R; VLDL receptor; very low density lipoprotein receptor]

products gene name :

[VLDLR]

other gene names :

[VLDLR; VLDLR; CARMQ1; CHRMQ1; VLDLRCH; VLDL receptor; VLDL-R]

uniprot entry name :

VLDLR_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

[1H10]

host :

Hybridoma cell culture.

reactivity :

Human

sequence length :

845

purity :

IgG fraction

form :

Frozen liquid; 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6

concentration :

4.74 mg/ml

storage stability :

Store at -70°C. Shelf Life: 5 years from delivery. Shipping: Ships in Dry Ice.

tested application :

ELISA (EIA), Western Blot (WB), BL

other info1 :

Immunogen: Recombinant fragment of soluble VLDL receptor containing ligand binding repeats 1-8 (sVLDLr1-8). Target: Recognises the C-terminus of VLDL receptor ligand binding domain (191-355). Target Molecular Weight: 85,000. Antigen: Recombinant fragment of soluble VLDL receptor containing ligand repeats 1-8 (sVLDLr1-8).

other info2 :

Extinction Coefficient: 1.36

products categories :

Receptor Associated Protein (RAP); Monoclonal Antibodies to Human VLDL Receptor

products description :

Monoclonal antibody produced in mouse. Useful for ELISA and western blot under non-reducing conditions. Binds to an epitope on the C-terminus of VLDL receptor ligand binding domain (amino acids 191-355, UniProtKB: locus VLDLR_HUMAN, accession P98155) and blocks apoE4 binding. Purified by immobilized Protein A. IgG1 class.

ncbi gi num :

65301164

ncbi acc num :

NP_001018066.1

ncbi gb acc num :

NM_001018056.1

uniprot acc num :

P98155

ncbi mol weight :

160,000

ncbi pathways :

Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Reelin Signaling Pathway (137980)

ncbi summary :

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]

uniprot summary :

VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 9p24. Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex. Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding. Biological Process: cholesterol metabolic process; nervous system development; receptor-mediated endocytosis; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; lipid transport; signal transduction; memory. Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1

size1 :

1 mg

price1 :

565 USD

size2 :

10 mg

price2 :

3930

more info or order :

MyBioSource product webpage