Biotin labeled Anti Human 515 kDa LRP | MyBioSource MBS135032 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin labeled Anti Human 515 kDa LRP

catalog :

MBS135032

quantity :

0.1 mg

price :

305 USD

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

[8G1]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, dot blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS135032

products type :

Antibody

products full name :

Biotin labeled Anti Human 515 kDa LRP

products short name :

[Biotin labeled Anti Human 515 kDa LRP]

other names :

[prolow-density lipoprotein receptor-related protein 1; Prolow-density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor; low density lipoprotein receptor-related protein 1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor]

products gene name :

[LRP1]

other gene names :

[LRP1; LRP1; APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD]

uniprot entry name :

LRP1_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa

clone :

[8G1]

host :

Mouse

reactivity :

Human

sequence length :

4544

purity :

IgG fraction

form :

Frozen liquid

concentration :

1.3 mg/ml; 12.1 moles biotin per mole antibody

storage stability :

Store at -70°C. Shipping conditions:Ships in Dry Ice. Minimum Shelf life: 5 years from delivery.

tested application :

Dot Blot (DB), EM, Flow Cytometry (FC), Immunohistochemistry (IHC) F/P, Immunofluorescence (IF), Western Blot (WB), Inhib, BL

other info1 :

Source: Mouse Ascites. Antigen: Full length native protein (purified) (Human). Target Information: Recognises the 515kDa alpha chain of Low Density LRP/alpha2 MR. Target Molecular Weight: 515000

other info2 :

Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36

products categories :

Receptor Associated Protein (RAP); Monoclonal Antibodies to Human LRP

products description :

Biotin labeled monoclonal antibody to human 515 kDa heavy chain of LRP. Purified by immobilized Protein A. IgG1k class.

ncbi gi num :

126012562

ncbi acc num :

NP_002323.2

ncbi gb acc num :

NM_002332.2

uniprot acc num :

Q07954

ncbi mol weight :

160,000

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Malaria Pathway (152665); Malaria Pathway (152657); PDGFR-beta Signaling Pathway (138071); Retinoid Metabolism And Transport Pathway (187208)

ncbi summary :

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

uniprot summary :

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung. Protein type: Cell surface; Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: focal adhesion; clathrin-coated vesicle; cell soma; lysosomal membrane; integral to plasma membrane; cytoplasm; dendrite; plasma membrane; nucleolus; coated pit; endosome; receptor complex. Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; receptor activity; calcium ion binding. Biological Process: phototransduction, visible light; receptor-mediated endocytosis; cholesterol metabolic process; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; regulation of cholesterol transport; retinoid metabolic process; apoptotic cell clearance; aging

size1 :

0.1 mg

price1 :

305 USD

size2 :

1 mg

price2 :

1855

more info or order :

MyBioSource product webpage