catalog number :
MBS135029
products full name :
Anti Human Prekallikrein, Clone 20E7
products short name :
[Prekallikrein, Clone 20E7]
other names :
[kallikrein-1 preproprotein; Kallikrein-1; kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein; kallikrein 1; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein]
products gene name :
[KLK1]
other gene names :
[KLK1; KLK1; hK1; KLKR; Klk6]
uniprot entry name :
KLK1_HUMAN
concentration :
1.97 mg/ml
storage stability :
Store at -70 degree C. Shelf Life: 5 years from delivery. Shipping Conditions: Dry Ice.
tested application :
ELISA (EIA), Capture, Western Blot (WB)
other info1 :
Immunogen: Full length native protein (purified) (Human). Target Information: Recognises the light chain of Prekallikrein. Target Molecular Weight: 86000
other info2 :
Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36
products categories :
Kallikrein/Prekallikrein; Monoclonal Antibodies to Human Prekallikrein
products description :
Mouse monoclonal antibody to human prekallikrein. Strongly blots prekallikrein and kallikrein under non-reducing and reducing conditions. Binding epitope is on the light chain of kallikrein. IgG fraction purified by immobilized Protein G. Clone 20E7-B7, isotype IgG2b.
ncbi acc num :
NP_002248.1
ncbi gb acc num :
NM_002257.2
ncbi mol weight :
160,000
ncbi pathways :
Blood Clotting Cascade Pathway (198840); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Metabolism Of Proteins Pathway (106230); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)
ncbi summary :
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
uniprot summary :
KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.35; Protease. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: nucleus. Molecular Function: serine-type endopeptidase activity. Biological Process: proteolysis. Disease: Kallikrein, Decreased Urinary Activity Of